Correction of metabolic changes in the tissues of oral cavity of rats using a complex of drugs under the conditions of pathological factors

Hypoxia is a typical pathological process that occurs when tissues are insufficiently supplied with oxygen or its utilization impaired. One of the most important pathogenetic factors in development tissue hypoxia disintegration structure mitochondrial membranes which under influence various etiological factors. In children who suffered antenatal period, frequency developmental delays significantly increased, and incidence caries also shown to increase as compared healthy children. Based on above, this work relevant for modern dentistry. The devoted study state maxillofacial system oral cavity rats complex drugs conditions intrauterine hypoxia, cariogenic diet, thyroid insufficiency fluorine deficiency. subjects were 25 female white Wistar line herd breeding from vivarium SE “ISMFS NAMS” kept standard diet. animals divided into three groups – intact (7 rats), pathology model (8 drug rats). Animals removed experiment thiopental anesthesia (40 mg/kg). Lower jaws pulp removed. As result research, it was established proposed treatment-prophylactic has pronounced caries-prophylactic periodontoprotective effect. caries-preventive effectiveness due ability stimulate mineralizing function dental pulp, namely, activity alkaline phosphatase an indicator activation osteoblasts, against background decrease acid phosphatase, marker osteoclasts.